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Improved adherence to preventive antiretroviral therapy may reduce transmission of HIV

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A recently completed substudy of a larger clinical trial found that pre-exposure prophylaxis—a new strategy to prevent HIV infection by prescribing a daily antiretroviral drug to at-risk individuals—can be a powerful tool when participants take their medications. The trial of this strategy, also called PrEP, enrolled uninfected individuals in East Africa with an HIV-positive sexual partner and found that a combination of objective monitoring of how often participants took their daily medications and intensive counseling of those with lower rates of adherence prevented any HIV infection among those receiving active medication during an average follow-up period of nearly one year.

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