In the field of drug design, the protein K-Ras is legendary. It's been on everyone's "target" list for more than 30 years due to its status as the most commonly mutated oncogene in human cancers. Despite this high profile, K-Ras has earned a reputation in scientific circles as being "undruggable" because many pharmaceutical, biotech, and academic laboratories have failed to design a drug that successfully targets the mutant gene.
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